Ovulation Induction:
Estradiol valerate: 2 mg twice daily for 5 days (from 8th day to 12th day of cycle)
Letrozole: 2.5 mg twice daily for 5 days (from 3rd day till 7th day of cycle)
Duration: 3 cycles
Intrauterine Insemination:
Estradiol Valerate: 6 or 8 mg daily in 3 or 4 divided doses (from 8th day till 12th day of cycle)
Duration: 3 cycles
In vitro fertilization:
Estradiol Valerate: 6 mg in 3 divided doses daily. From 1st to 28th day of the cycle 600 mg progesterone in 3 divided doses daily from 14th to 28th day of the cycles
Duration: 8 weeks of the cycle
The following diseases are reported more often in women using HRT compared to women not using HRT:
breast cancer
abnormal growth or cancer of the lining of the womb (endometrial hyperplasia or cancer)
ovarian cancer
blood clots in the veins of the legs or lungs (venous thromboembolism)
heart disease
stroke
probable memory loss if HRT is started over the age of 65 Other side effects that have been linked to the use of Estradiol Valerate and other oral hormone replacement therapies
During the first few months of treatment you may experience some vaginal bleeding at unexpected times (breakthrough bleeding and spotting). These symptoms normally lessen with continued treatment. If they don’t, contact your doctor (see section 2 HRT and cancer/Excessive thickening of the lining of the womb (endometrial hyperplasia) and cancer of the lining of the womb (endometrial cancer)’ for more information)
breast pain, tenderness or enlargement, breast discharge
painful periods, changes in vaginal secretions, pre-menstrual symptoms, increased size of fibroids in the womb, thrush, changes to the neck of the womb
indigestion, a feeling of being bloated, passing wind, feeling or being sick, abdominal pain, gall bladder disease
skin rashes or discolouration, itching, eczema, acne, unusual hair loss or hair growth, increased skin pigment especially on the face (chloasma other conditions for more information), some rare skin problems
headache, migraine, dizziness, anxiety or depressive symptoms, fatigue
fast or irregular heartbeat (palpitations), high blood pressure, inflammation of veins usually in the legs
fluid retention leading to swelling of parts of the body
changes in body weight and sex drive, increased appetite
muscle cramps, leg pains
nose bleeds, visual disturbances (such as blurred vision), discomfort with contact lenses, allergic-type reactions, a worsening of glucose tolerance, bladder inflammation, rare disorders (porphyria, chorea).
Drugs for menopausal symptoms: Hormone replacement therapy, Female Sex hormones
Store below 30°C and dry place. Keep away from light. Keep out of the reach of children.
