Description

Norethisterone tablet is a preparation of Norethisterone which has progestational actions similar to those of progesterone, but is a more potent inhibitor of ovulation and has weak estrogenic and androgenic properties. It is used to treat a number of disorders of the menstrual cycle. Norethisterone is absorbed from the gastrointestinal tract and its effects last for at least 24 hours. It is excreted in the urine.

Not known.

Pregnancy Severe disturbances of liver function Dubin-Johnson syndrome Rotor syndrome Previous or existing liver tumours History during pregnancy of idiopathic jaundice, severe pruritus or herpes gestationis Current thromboembolic processes Hypersensitivity to the active substances or to any of the excipients

Side-effects are more common during the first months after start of intake of Norethisterone, and subside with a duration of treatment. The side-effects are mentioned below: Eye disorders- Visual disturbance GI disorders- Nausea General disorders and administration site- conditions headache, edema Nervous system disorders- Migraine, Respiratory, thoracic and mediastinal disorders- Dyspnoea, Skin and subcutaneous tissue disorders- Hypersensitivity (eg. Rash, urticaria).

The administration of Norethisterone during pregnancy is contraindicated. Norethisterone should not be used during lactation.

There is a general opinion, based on statistical evidence that users of combined oral contraceptives experience, more often than non-users, venous thromboembolism, arterial thrombosis, including cerebral and myocardial infarction and subarachnoid haemorrhage. Full recovery from such disorders does not always occur, and it should be realized that in a few cases they are fatal. Although Norethisterone does not contain oestrogen, one should keep the possibility of an increased thromboembolic risk in mind, particularly where there is a history of thromboembolic disease or in the presence of severe diabetes with vascular changes or sickle-cell anaemia. In rare cases benign, and in even rarer cases, malignant liver tumours leading in isolated cases to life-threatening intra-abdominal haemorrhage have been observed after the use of hormonal substances such as the one contained in Norethisterone. If severe upper abdominal complaints, liver enlargement or signs of intra-abdominal haemorrhage occur, a liver tumour should be included in the differential diagnosis and, if necessary, the preparation should be withdrawn. Norethisterone can influence carbohydrate metabolism. Parameters of carbohydrate metabolism should be examined carefully in all diabetics before and regularly during treatment. Reasons for stopping Norethisterone immediately- Occurrence for the first time of migrainous headaches or more frequent occurrence of unusually severe headaches Sudden perceptual disorders (e.g. disturbances of vision or hearing) First signs of thrombophlebitis or thromboembolic symptoms, feeling of pain and tightness in the chest Pending operations (six weeks beforehand), immobilisation (e.g. after accidents) Onset of jaundice, hepatitis, general pruritus Significant rise in blood pressure Pregnancy.

There have been no reports from overdosage and treatment is generally unnecessary. There are no special antidotes and treatment should be symptomatic.