Caution should be exercised with concomitant administration of Antacids, Azathioprine, Cyclosporin, Rifampin, Sevelamer, Cholestyramine, Acyclovir, Metronidazole, Hormonal contraceptives as these medicines may decrease Mycophenolic acid concentration.
The most common adverse reactions (≥20%) associated with the administration of Mycophenolic acid are anemia, leukopenia, constipation, diarrhea, vomiting, dyspepsia, urinary tract infection, CMV infection, insomnia, and postoperative pain.
Pregnancy Category D. Can cause fetal harm.
Lactation: Discontinue Mycophenolic acid or discontinue nursing while on treatment or within 6 weeks after stopping therapy. Take into consideration the importance of the drug to the mother.
Mycophenolic acid tablets are used with caution because it-
Can cause embryofetal toxicity
Can increase new or reactive viral infections
Can cause blood dyscrasias including pure red cell aplasia
Can cause serious GI tract complications (gastrointestinal bleeding, perforations and ulcers)
May increase the risk of developing lymphomas and other malignancies, particularly of the skin
Use of live vaccine should be avoided during treatment with Mycophenolic acid