Ivermectin, a member of the avermectin class, causes death of parasites, primarily through binding selectively and with high affinity to glutamate-gated chloride channels, which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligandgated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The selective activity of compounds of this class is attributable to the fact that some mammals do not have glutamate-gated chloride channels, the avermectins have a low affinity for mammalian ligand-gated chloride channels, and Ivermectin does not readily cross the blood-brain barrier in humans.
Common side effects are-
Conjunctivitis
Ocular hyperemia
Eye irritation
Dandruff
Dry skin
Skin burning sensation etc.
Pregnancy Category C. There are no adequate and well-controlled studies with Ivermectin Lotion in pregnant women. Ivermectin Lotion should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Following oral administration, Ivermectin is excreted in human milk in low concentrations. This has not been evaluated following topical administration. Caution should be exercised when Ivermectin Lotion is administered to a nursing woman.
Accidental ingestion in pediatric patients may occur administer only under direct adult supervision.
Tips to prevent the spreading of lice:
Avoid direct head-to-head contact with anyone known to have live, crawling lice.
Do not share combs, brushes, hats, scarves, bandannas, ribbons, hair bands, towels, helmets, or other hair-related personal items with anyone else, whether they have lice or not.
After finishing treatment with anti-lice medicine, check everyone in your family for lice after one week. Be sure to talk to your healthcare provider about treatments for those who have lice.
Miscellaneous topical agents
Keep away from light & wet place. Keep out of reach of children.
