Hypersensitivity reaction, optic neuritis, in case of black water fever etc.
In pregnancy, the quinine is not necessarily contraindicated. It is considered to be safe when used in therapeutic dosage in pregnancy. It is excreted in breast milk in insignificant amount which does not discard the use in lactation.
Severe heart disease, myasthenia gravis, diabetes mellitus, IV injection should be given slowly. Use of Mefloquine with Quinine sulphate may increase the chance of side effects.
Anti-malarial drugs
Use of Mefloquine with Quinine sulphate may increase the chance of side effects.