Description

Gentamicin belongs to the group of aminoglycoside antibiotics. It covers a broad spectrum of gram-positive and gram-negative pathogens, including Pseudomonas aeruginosa, Staphylococci, Haemophilus influenzae H. aegypticus, Klebsiella, Enterobacteria, Proteus, Escherichia coli, Shigella and Salmonella. It inhibits specifically bacterial protein synthesis. Fluorometholone is a synthetic fluorinated corticosteroid possessing anti-inflammatory properties. The combination brings concomitantly the bacterial treatment or prophylaxis and the anti-inflammatory effect. In addition, the presence of gentamicin protects from a risk of potential aggravation of a bacterial infection due to the steroid.

A transient burning sensation may occur after instillation. Rare: Hypersensitivity reactions including eczema of the eyelid and puncture keratitis. Prolonged use of topical steroids may delay wound healing, increase of IOP, develop cataract and cause thinning of cornea & sclera.

No controlled studies in humans are available. Administration during pregnancy and lactation is therefore not recommended, except for compelling reasons.

Steroids can mask, activate or aggravate ocular infections. Long-term treatment with steroid may enhance thinning of cornea and sclera and rarely perforation of the cornea has been reported.  In case no improvement is observed after 7-8 days of treatment, other therapeutical means should be considered.  Patients experiencing blurred vision after application of the product, particularly the ointment, should refrain from driving vehicles or operating machinery. Contact lenses should be removed before each application.

Ophthalmic steroid - antibiotic combined preparations

Store in a cool and dry place, protect from light. Do not use longer than 30 days after first opening. Keep out of reach of children.